Hydrochloric Acid → 4-Fluoro-cinnamyl chloride

273.6 g (1.798 mol) of 1-(4-fluorophenyl)allyl alcohol were dissolved with stirring in 2,000 ml of methylene chloride. Subsequently, 101.0 g (2,770 mol) of hydrogen chloride were passed in over the course of 3 h, during which the temperature rose to 37° C. The mixture was then stirred for 1 h. After washing with 600 ml of ice-cold water and a mixture of 150 ml of saturated brine and 150 ml of water, the organic phase was dried over sodium sulfate and concentrated. 294.6 g (98%) of a brown oil were obtained.

1. customwere passed in over the course of 3 h, during which
2. customrose to 37° C
3. washAfter washing with 600 ml of ice-cold water
4. additiona mixture of 150 ml of saturated brine and 150 ml of water
5. dry with materialthe organic phase was dried over sodium sulfate
6. concentrationconcentrated

ORD-Eintrag

ord-9c2abfae17fa4ef4a5431eb346963d08

Quelldatensatz

uspto-grants-1995_12

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US05473080