Hydrochloric Acid → HCID 18398665, Verbindung
Reaktionsgleichung
Cl.[S:2]1[C:10]2[C:5](=[N:6][C:7]([C:11]([OH:13])=[O:12])=[CH:8][CH:9]=2)[CH:4]=[CH:3]1.[CH3:14]O>>[S:2]1[C:10]2[C:5](=[N:6][C:7]([C:11]([O:13][CH3:14])=[O:12])=[CH:8][CH:9]=2)[CH:4]=[CH:3]1Komponenten
4
Versuchsvorschrift
To a solution of HCl (10%) in MeOH (10 mL) was added thieno[3,2-b]pyridine-5-carboxylic acid (1.0 g, 5.6 mmol, from Step 2, Example 1) and the mixture heated to reflux for 2 hr. After cooling to r.t., half the solvent was removed by evaporation and the remainder was partitioned between EtOAc and H2O. Solid NaHCO3 was added until the system remained basic. Separation, drying, and evaporation of the organic layer afforded 0.75 g (70%) of methyl thieno[3,2-b]pyridine-5-carboxylate.
Aufarbeitung
- temperaturethe mixture heated
- temperatureto reflux for 2 hr
- customhalf the solvent was removed by evaporation
- customthe remainder was partitioned between EtOAc and H2O
- additionSolid NaHCO3 was added until the system
- customSeparation
- customdrying
- customevaporation of the organic layer
Quellen und Nachweise
- ORD-Eintrag
- ord-dd3464fd6aef4c03888ce3d35671013e
- Quelldatensatz
- uspto-grants-1995_12
- Patentnummer
- US05472964
Notizen zur Reaktion
Wird geladen…