Potassium Hydroxide → N-(2,3-dihydroxypropyl)-N-hexadecyl-2-hydroxyoctanamide

HRID 2260078

Reaktionsgleichung

Reaktionsgleichung von HRID 2260078
[OH:1][CH:2]([CH2:21][OH:22])[CH2:3][NH:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20].[OH-].[K+].C[O:26][C:27](=O)[CH:28]([OH:35])[CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH3:34]>>[OH:1][CH:2]([CH2:21][OH:22])[CH2:3][N:4]([CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20])[C:27](=[O:26])[CH:28]([OH:35])[CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH3:34]

Komponenten

4

Edukt 3

HCID 14797Potassium HydroxideHCID 1110073-(Hexadecylamino)propane-1,2-diolHCID 10487462Methyl 2-hydroxyoctanoate

Produkt 1

HCID 10217103N-(2,3-dihydroxypropyl)-N-hexadecyl-2-hydroxyoctanamide

Versuchsvorschrift

N-(2,3-dihydroxypropyl)-hexadecylamine (1.0 g, 3.2 mmoles) and potassium hydroxide (0.01 g, 0.18 mmoles) were heated to 85° C. under vacuum and methyl-2-hydroxyoctanoate (0.55 g, 3.2 mmoles) was added dropwise to the reaction. The reaction was heated under vacuum for 6 hours. A waxy off white solid was obtained (crude yield=1,39 g), and the waxy solid further purified by recrystallization in hot hexane. (Yield=0.88g).

Aufarbeitung

  1. additionwas added dropwise to the reaction
  2. temperatureThe reaction was heated under vacuum for 6 hours
  3. customA waxy off white solid was obtained (crude yield=1,39 g)
  4. customthe waxy solid further purified by recrystallization in hot hexane

Quellen und Nachweise

ORD-Eintrag
ord-a7d2978f0e4e4f0da0d2ac2365b13e60
Quelldatensatz
uspto-grants-1995_12
Patentnummer
US05476661

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