Hexanoyl chloride → HCID 18999305, Verbindung

HRID 2260080

Reaktionsgleichung

Reaktionsgleichung von HRID 2260080
[C:1](Cl)(=[O:7])[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].[OH:9][CH:10]([CH2:29][OH:30])[CH2:11][NH:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28]>C(Cl)(Cl)Cl>[OH:9][CH:10]([CH2:29][OH:30])[CH2:11][N:12]([CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])[C:1](=[O:7])[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6]

Komponenten

4

Edukt 2

HCID 67340Hexanoyl chlorideHCID 1110073-(Hexadecylamino)propane-1,2-diol

Produkt 1

HCID 18999305HCID 18999305, VerbindungAusbeute 19,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

Hexanoyl chloride (2.65g, 19.7 mmoles) was added dropwise to a reactor containing N-(2,3-dihydroxypropyl)-hexadecylamine (2.65g, 19.7 mmoles)in 8 mL of chloroform. The reaction was stirred for 16 hours at room temperature. When the reaction was completed, the mixture was concentrated, ethanol and water was added, and the pH of the reaction was adjusted to 14. This mixture was extracted with chloroform, and organic layer was collected and concentrated. The crude sample was purified on silica column chromatography to give 1.56 g of product.

Aufarbeitung

  1. concentrationthe mixture was concentrated
  2. additionethanol and water was added
  3. extractionThis mixture was extracted with chloroform, and organic layer
  4. customwas collected
  5. concentrationconcentrated
  6. customThe crude sample was purified on silica column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-889bd1ab51a340bc9c1000bbfc525480
Quelldatensatz
uspto-grants-1995_12
Patentnummer
US05476661

Verknüpfte Notizen

Wird geladen…