1H-Indazole-5,6-diamine → 6-(5-chlorothien-2-yl)-1H-pyrazolo[3,4-g]quinoxaline 7-(5-chlorothien-2-yl)-1H-pyrazolo[3,4-g]quinoxaline

HRID 2260110

Reaktionsgleichung

Reaktionsgleichung von HRID 2260110
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[NH2:11])[NH:7][N:6]=[CH:5]2.[Cl:12][C:13]1[S:14][C:15]([C:18](=O)[CH:19]=O)=[CH:16][CH:17]=1>C(O)C>[Cl:12][C:13]1[S:14][C:15]([C:18]2[CH:19]=[N:1][C:2]3[CH:3]=[C:4]4[CH:5]=[N:6][NH:7][C:8]4=[CH:9][C:10]=3[N:11]=2)=[CH:16][CH:17]=1.[Cl:12][C:13]1[S:14][C:15]([C:18]2[CH:19]=[N:11][C:10]3[CH:9]=[C:8]4[NH:7][N:6]=[CH:5][C:4]4=[CH:3][C:2]=3[N:1]=2)=[CH:16][CH:17]=1

Komponenten

4

Edukt 2

HCID 819001H-Indazole-5,6-diamineHCID 187887102-Chloro-5-glyoxyloylthiophene

Produkt 1

HCID 189998206-(5-chlorothien-2-yl)-1H-pyrazolo[3,4-g]quinoxaline 7-(5-chlorothien-2-yl)-1H-pyrazolo[3,4-g]quinoxaline

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel2×

Versuchsvorschrift

To a mixture of 5,6-diaminoindazole (0.5 g) in 30 ml absolute ethanol is added slowly a solution of 2-chloro-5-glyoxyloylthiophene (0.72 g) and 20 ml ethanol. The resulting mixture is stirred at room temperature for 4.5 hours. The yellow solid which forms is filtered off, washed with ethanol then with hexane and air dried overnight.

Aufarbeitung

  1. filtrationThe yellow solid which forms is filtered off
  2. washwashed with ethanol
  3. dry with materialwith hexane and air dried overnight

Quellen und Nachweise

ORD-Eintrag
ord-5922bbc9349b42c8bc5ca660f6846243
Quelldatensatz
uspto-grants-1995_12
Patentnummer
US05476851

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