HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 2260535Erstellt: 26. Oktober 2026
Sulfur → 2-(4-Fluorophenyl)-3-(2-methylpyridin-4-yl)pyrazolo[1,5-a]pyrimidine
https://huagongshe.com/reaction/2260535
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Sulfur | HCID 5362487 | — |
| Edukt | 3-(1-Acetyl-l,2-dihydro-2-methylpyridin-4-yl)-2-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidine | HCID 19957261 | — |
| Lösungsmittel | Decalin | HCID 7044 | — |
| Produkt | 2-(4-Fluorophenyl)-3-(2-methylpyridin-4-yl)pyrazolo[1,5-a]pyrimidine | HCID 19957277 | 49,1% |
Reaktionsschritte
A mixture of 3-(1-acetyl-1,2-dihydro-2-methylpyridin-4-yl)-2-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidine (315 mg) and sulfur (146 mg) in decaline (3 ml) was stirred at 190° C. for 2 hours. The reaction mixture was cooled and purified by column chromatography on silica gel to give 2-(4-fluorophenyl)- 3-(2-methylpyridin-4-yl) pyrazolo[1,5-a]pyrimidine (135 mg) as crystals.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patentnummer | US05478827 |
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| Quelldatensatz | uspto-grants-1995_12 |
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| ORD ID | ord-8a74a79e7f544fd890fbc182cee36d45 |
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| Quellennotiz | uspto-grants-1995_12 |
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