Reaktionsgleichung
[CH3:1][O:2][C:3]1[N:8]=[N:7][C:6]([NH:9][C:10](=[O:15])[C:11]([CH3:14])([CH3:13])[CH3:12])=[CH:5][CH:4]=1.[CH3:16][CH2:17][CH:18](Br)[CH2:19][CH3:20]>>[CH2:17]([CH:18]([C:5]1[CH:4]=[C:3]([O:2][CH3:1])[N:8]=[N:7][C:6]=1[NH:9][C:10](=[O:15])[C:11]([CH3:12])([CH3:14])[CH3:13])[CH2:19][CH3:20])[CH3:16]Komponenten
3
Versuchsvorschrift
Using a procedure analogous to Example 17B, from N-(6-methoxy-pyridazin-3-yl)-2,2-dimethyl-propionamide (6.09 g, 29.14 mmol) and Grignard reagent prepared from 3-pentyl bromide (18.1 mL, 160.3 mmol) and Mg (3.84 g, 160.26 mmol) gives the title compound (5.32 g, 19.1 mmol, 65%). 1H NMR (CDCl3): δ. 0.84 (t, J=7.5 Hz, 6H), 1.36 (s, 9H), 1.50-1.72 (m, 4H), 3.50-3.70 (m, 1H), 4.07 (s, 3H), 6.96 (s, 1H) ppm. ES-MS (m/z): calcd for C15H25N3O2 (M+H)+: 280.4. found: 280.2.
Quellen und Nachweise
- ORD-Eintrag
- ord-03c457f3210a43cda4752dde6f12390a
- Quelldatensatz
- uspto-grants-2009_07
- Patentnummer
- US07557103B2
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