4-(Bromomethyl)thiophene-2-carbonitrile → 4-{3-Fluoro-4-[2-(S)-(2-(R)-methyl-pyrrolidin-1-ylmethyl)-pyrrolidine-1-carbonyl]-phenoxymethyl}-thiophene-2-carbonitrile
Reaktionsgleichung
[F:1][C:2]1[CH:7]=[C:6]([OH:8])[CH:5]=[CH:4][C:3]=1[C:9]([N:11]1[CH2:15][CH2:14][CH2:13][C@H:12]1[CH2:16][N:17]1[CH2:21][CH2:20][CH2:19][C@H:18]1[CH3:22])=[O:10].Br[CH2:24][C:25]1[CH:26]=[C:27]([C:30]#[N:31])[S:28][CH:29]=1>>[F:1][C:2]1[CH:7]=[C:6]([CH:5]=[CH:4][C:3]=1[C:9]([N:11]1[CH2:15][CH2:14][CH2:13][C@H:12]1[CH2:16][N:17]1[CH2:21][CH2:20][CH2:19][C@H:18]1[CH3:22])=[O:10])[O:8][CH2:24][C:25]1[CH:26]=[C:27]([C:30]#[N:31])[S:28][CH:29]=1Komponenten
3
Edukt 2
Produkt 1
Versuchsvorschrift
The title compound is prepared in a manner substantially analogous to Procedure C from (2-Fluoro-4-hydroxy-phenyl)-[2-(S)-(2-(R)-methyl-pyrrolidin-1-ylmethyl)-pyrrolidin-1-yl]-methanone and 4-bromomethyl-thiophene-2-carbonitrile [CAS 186552-07-8]. MS (ES+) m/e 428.3