4-Methyl-2-oxovaleric acid → Methyl 4-methyl-2-oxopentanoate

HRID 2261726Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2261726
[CH3:1][CH:2]([CH3:9])[CH2:3][C:4](=[O:8])[C:5]([OH:7])=[O:6].Cl[Si](C)(C)[CH3:12]>CO.COC(OC)(C)C>[CH3:12][O:6][C:5](=[O:7])[C:4](=[O:8])[CH2:3][CH:2]([CH3:9])[CH3:1]

Komponenten

5

Edukt 2

HCID 704-Methyl-2-oxovaleric acidHCID 6397Chlorotrimethylsilane

Produkt 1

HCID 546077Methyl 4-methyl-2-oxopentanoate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 64952,2-DimethoxypropaneLösungsmittel

Versuchsvorschrift

To a solution of 4-methyl-2-oxo-pentanoic acid (3.4 g, 26 mmol) in methanol (12 mL) and 2,2-dimethoxypropane (48 mL) is added chlorotrimethylsilane (0.38 mL). The reaction mixture is stirred at ambient temperature overnight. The reaction mixture is concentrated under reduced pressure to give the title compound as an oil, (3.8 g, quant.). 1H NMR (400 MHz, CDCl3): δ 3.86 (s, 3H), 2.72 (d, 2H), 2.16 (m, 1H), 0.96 (d, 6H).

Aufarbeitung

  1. concentrationThe reaction mixture is concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-9c94aee87db64cf4a8fffb905caea73e
Quelldatensatz
uspto-grants-2010_12
Patentnummer
US07846960B2

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