3-phenyl-4-(1-phenyl-1H-imidazol-4-yl)-5-trifluoromethyl-isoxazole → 1-[3-(3-Fluoro-phenyl)-5-trifluoromethyl-isoxazol-4-yl]-ethanone
Reaktionsgleichung
[F:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:12]=[C:11]([C:13]([F:16])([F:15])[F:14])[O:10][N:9]=2)[CH:5]=[CH:6][CH:7]=1.C1(C2[C:27](C3N=CN(C4C=CC=CC=4)C=3)=[C:26](C(F)(F)F)[O:25]N=2)C=CC=CC=1>>[F:1][C:2]1[CH:3]=[C:4]([C:8]2[C:12]([C:26](=[O:25])[CH3:27])=[C:11]([C:13]([F:14])([F:15])[F:16])[O:10][N:9]=2)[CH:5]=[CH:6][CH:7]=1Komponenten
3
Versuchsvorschrift
As described for Example 1e, 3-(3-fluoro-phenyl)-5-trifluoromethyl-isoxazole (20 g, 86.5 mmol), instead of 3-phenyl-4-(1-phenyl-1H-imidazol-4-yl)-5-trifluoromethyl-isoxazole, was converted to the title compound (12.2 g, 51%) which was obtained as a light yellow oil. MS: m/e=272.1 [M−H]−.
Quellen und Nachweise
- ORD-Eintrag
- ord-b7deece7cb354a448ec29a806b67e467