Trifluoroacetic acid → N-1,2-Benzisoxazol-3-ylpiperazine-1-carboxamide trifluoroacetate

HRID 2262875Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2262875
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([NH:10][C:11]([N:13]2[CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][CH2:14]2)=[O:12])=[N:2]1.[F:26][C:27]([F:32])([F:31])[C:28]([OH:30])=[O:29]>>[F:26][C:27]([F:32])([F:31])[C:28]([OH:30])=[O:29].[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([NH:10][C:11]([N:13]2[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]2)=[O:12])=[N:2]1

Komponenten

3

Edukt 2

HCID 6422Trifluoroacetic acidHCID 68724498HCID 68724498, Verbindung

Produkt 1

HCID 68778018N-1,2-Benzisoxazol-3-ylpiperazine-1-carboxamide trifluoroacetateAusbeute 95,3 %

Versuchsvorschrift

A solution of tert-butyl 4-[(1,2-benzisoxazol-3-ylamino)carbonyl]piperazine-1-carboxylate (16.5 g, 47.6 mmol) in trifluoroacetic acid (200 ml) was stirred at room temperature for 2 hours, and then the solvent was distilled off under reduced pressure. The residue was recrystallized from a mixed solvent of methanol and diethyl ether to give 16.3 g (95.3%) of the desired product.

Aufarbeitung

  1. distillationthe solvent was distilled off under reduced pressure
  2. customThe residue was recrystallized from a mixed solvent of methanol and diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-2aaf775f07e84c9a8b3b3b4f0b597d0d
Quelldatensatz
uspto-grants-2010_12
Patentnummer
US07851473B2

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