Sodium Hydroxide → 1-(4-Phenyl-2-thienyl)piperazine

HRID 2263054Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2263054
[C:1]1([C:7]2[CH:8]=[C:9]([N:12]3[CH2:17][CH2:16][N:15](C(OCC)=O)[CH2:14][CH2:13]3)[S:10][CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+]>C(O)C>[C:1]1([C:7]2[CH:8]=[C:9]([N:12]3[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]3)[S:10][CH:11]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 68776928Ethyl 4-(4-phenyl-2-thienyl)piperazine-1-carboxylate

Produkt 1

HCID 687773121-(4-Phenyl-2-thienyl)piperazineAusbeute 88,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of ethyl 4-(4-phenyl-2-thienyl)piperazine-1-carboxylate (350 mg, 1.11 mmol), an aqueous 8N sodium hydroxide solution (5 ml) and ethanol (10 ml) was stirred at 100° C. for 3 hours, and the solvent was distilled off under reduced pressure. The residue was poured into water and the mixture was extracted with chloroform. The extract was dried over anhydrous magnesium sulfate and the solvent was distilled off under reduced pressure to obtain the desired product (240 mg, 88.9%) as an oil.

Aufarbeitung

  1. distillationthe solvent was distilled off under reduced pressure
  2. additionThe residue was poured into water
  3. extractionthe mixture was extracted with chloroform
  4. dry with materialThe extract was dried over anhydrous magnesium sulfate
  5. distillationthe solvent was distilled off under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-bfd9f8f126d74528a7d5c78541ca744c
Quelldatensatz
uspto-grants-2010_12
Patentnummer
US07851473B2

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