Pyridine → HCID 21408261, Verbindung

HRID 2263361

Reaktionsgleichung

Reaktionsgleichung von HRID 2263361
[C:1]1([C:7]2[NH:8][C:9](=O)[O:10][CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.N1C=CC=CC=1.P(Cl)(Cl)([Cl:21])=O>>[Cl:21][C:9]1[O:10][CH:11]=[C:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[N:8]=1

Komponenten

4

Edukt 3

HCID 1049PyridineHCID 24813Phosphorus oxychlorideHCID 1186694-Oxazolin-2-one, 4-phenyl-

Produkt 1

HCID 21408261HCID 21408261, VerbindungAusbeute 15,7 %

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

To a solution of 4-phenyl-1,3-oxazol-2(3H)-one (1.00 g, 62.0 mmol) in phosphorus oxychloride (18 ml) was added pyridine (0.974 ml, 12.0 mmol), and the mixture was stirred at 100° C. for 1 hour and 20 minutes. The solvent was distilled off under reduced pressure. The residue was purified by silica gel column chromatography (hexane: ethyl acetate=9:1) to give 176 mg (15.7%) of the desired product as a solid.

Aufarbeitung

  1. distillationThe solvent was distilled off under reduced pressure
  2. customThe residue was purified by silica gel column chromatography (hexane: ethyl acetate=9:1)

Quellen und Nachweise

ORD-Eintrag
ord-5090c86d84594faf94a90ff756da590d
Quelldatensatz
uspto-grants-2010_12
Patentnummer
US07851473B2

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