gamma-Hydroxypropyl ethyl sulfide → [(4S,5R)-2-(4-tert-Butyl-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazol-1-yl]-[4-(3-ethanesulfonyl-propyl)-piperazin-1-yl]-methanone

HRID 2264047

Reaktionsgleichung

Reaktionsgleichung von HRID 2264047
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[NH:12][C@@:13]([C:25]3[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][CH:26]=3)([CH3:24])[C@@:14]([C:17]3[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=3)([CH3:16])[N:15]=2)=[C:7]([O:32][CH2:33][CH3:34])[CH:6]=1)([CH3:4])([CH3:3])[CH3:2].Cl.Cl.[CH2:37]([S:39]([CH2:42][CH2:43][CH2:44][N:45]1[CH2:50][CH2:49][NH:48][CH2:47][CH2:46]1)(=[O:41])=[O:40])[CH3:38].C(SCC[CH2:56][OH:57])C.Cl.Cl.CS(CCCN1CCNCC1)(=O)=O>>[C:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[N:15]([C:56]([N:48]3[CH2:49][CH2:50][N:45]([CH2:44][CH2:43][CH2:42][S:39]([CH2:37][CH3:38])(=[O:41])=[O:40])[CH2:46][CH2:47]3)=[O:57])[C@@:14]([C:17]3[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=3)([CH3:16])[C@@:13]([C:25]3[CH:26]=[CH:27][C:28]([Cl:31])=[CH:29][CH:30]=3)([CH3:24])[N:12]=2)=[C:7]([O:32][CH2:33][CH3:34])[CH:6]=1)([CH3:2])([CH3:3])[CH3:4]

Komponenten

5

Edukt 4

HCID 87762gamma-Hydroxypropyl ethyl sulfideHCID 498534791-(3-(Methylsulfonyl)propyl)piperazine dihydrochlorideHCID 67071354(4R,5S)-2-(4-tert-Butyl-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dimethyl-4,5-dihydro-1H-imidazoleHCID 670715001-(3-Ethanesulfonyl-propyl)-piperazine dihydrochloride

Produkt 1

HCID 58894220[(4S,5R)-2-(4-tert-Butyl-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazol-1-yl]-[4-(3-ethanesulfonyl-propyl)-piperazin-1-yl]-methanone

Versuchsvorschrift

In a manner analogous to the method described in example 5, (4S,5R)-2-(4-tert-butyl-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-1H-imidazole (example 4) was reacted with 1-(3-ethanesulfonyl-propyl)-piperazine dihydrochloride (prepared from 3-ethylsulfanyl-propan-1-ol in an analogous manner as the method described for 1-(3-methanesulfonyl-propyl)-piperazine dihydrochloride) to give the title compound. HR-MS (ES, m/z) calculated for C39H51N4O4SCl2 [(M+H)+] 741.3003, observed 741.2998.

Quellen und Nachweise

ORD-Eintrag
ord-9b9fbf6d6acd42659e0a064759230e44
Quelldatensatz
uspto-grants-2010_12
Patentnummer
US07851626B2

Verknüpfte Notizen

Wird geladen…