Hydrochloric Acid → HCID 178478869, Verbindung

HRID 2264425Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2264425
C(OC([N:6]1[CH2:11][CH2:10][CH:9]([NH:12][C:13]2[N:18]=[C:17]([O:19]C)[CH:16]=[CH:15][N:14]=2)[CH2:8][CH2:7]1)=O)C.[ClH:21]>C(O)C>[ClH:21].[ClH:21].[NH:6]1[CH2:7][CH2:8][CH:9]([NH:12][C:13]2[N:18]=[C:17]([OH:19])[CH:16]=[CH:15][N:14]=2)[CH2:10][CH2:11]1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 24237580Ethyl 4-[(4-methoxypyrimidin-2-yl)amino]piperidine-1-carboxylate

Produkt 1

HCID 178478869HCID 178478869, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of 4-(4-methoxy-pyrimidin-2-ylamino)-piperidine-1-carboxylic acid ethyl ester (1.5 g, 5.35 mmol) in ethanol (50 mL) and conc. HCl (75 mL) was heated to reflux for 18 h. The solvent was removed under reduced pressure and the crude product used in the consecutive step without further purification assuming quantitative deprotection and formation of the dihydrochloride salt. MS (ISP): 194.9 [M+H]+.

Aufarbeitung

  1. temperatureto reflux for 18 h
  2. customThe solvent was removed under reduced pressure
  3. customthe crude product used in the consecutive step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-c15ad42c7ced438db05870c50bbf275b
Quelldatensatz
uspto-grants-2010_12
Patentnummer
US07855194B2

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