Potassium Carbonate → 4-Bromo-3-fluorophenyl (2-fluorophenyl)methyl ether

HRID 2264807

Reaktionsgleichung

Reaktionsgleichung von HRID 2264807
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][C:3]=1[F:9].[F:10][C:11]1[CH:18]=[CH:17][CH:16]=[CH:15][C:12]=1[CH2:13]Br.C(=O)([O-])[O-].[K+].[K+]>>[F:10][C:11]1[CH:18]=[CH:17][CH:16]=[CH:15][C:12]=1[CH2:13][O:8][C:5]1[CH:6]=[CH:7][C:2]([Br:1])=[C:3]([F:9])[CH:4]=1

Komponenten

4

Edukt 3

HCID 11430Potassium CarbonateHCID 67968alpha-Bromo-o-fluorotolueneHCID 27791534-Bromo-3-fluorophenol

Produkt 1

HCID 595967064-Bromo-3-fluorophenyl (2-fluorophenyl)methyl etherAusbeute 108,5 %

Versuchsvorschrift

A solution of 4-bromo-3-fluorophenol (5 g, 25 mmol), 2-fluorobenzylbromide (4.94 g, 26 mmol) and potassium carbonate (5.39 g, 39 mmol) was stirred at room temperature for 6 h. The solvent was evaporated, the residue taken up in water and extracted with ethyl acetate. The combined organic layers were dried over Na2SO4, filtered and evaporated under reduced pressure, affording the title compound (8.11 g) as a white solid; Rt (HPLC) 6.31 min.

Aufarbeitung

  1. customThe solvent was evaporated
  2. extractionextracted with ethyl acetate
  3. dry with materialThe combined organic layers were dried over Na2SO4
  4. filtrationfiltered
  5. customevaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-75646b0819354432b69d277c7f52234c
Quelldatensatz
uspto-grants-2010_12
Patentnummer
US07855218B2

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