Toluene → 80854-57-5

HRID 2265114Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2265114
[CH3:1][C:2]([C:4]1[CH:9]=[CH:8][C:7]([N+:10]([O-:12])=[O:11])=[CH:6][CH:5]=1)=O.[C:13](C=P(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)([O:15][CH2:16][CH3:17])=[O:14].[C:38]1(C)C=CC=CC=1>>[N+:10]([C:7]1[CH:8]=[CH:9][C:4](/[C:2](/[CH3:38])=[CH:1]/[C:13]([O:15][CH2:16][CH3:17])=[O:14])=[CH:5][CH:6]=1)([O-:12])=[O:11]

Komponenten

4

Edukt 3

HCID 1140TolueneHCID 7487p-NitroacetophenoneHCID 70670Acetic acid, 2-(triphenylphosphoranylidene)-, ethyl ester

Produkt 1

HCID 614540480854-57-5Ausbeute 29 %

Versuchsvorschrift

A toluene (90 ml) solution of 4-nitroacetophenone (2.0 g) and (carbethoxymethylidene)triphenylphosphorane (6.33 g) was stirred while refluxing under heating for 10 hours. After the solution was allowed to cool, the solvent was distilled off. The obtained residue was purified by column chromatography (6.25% ethyl acetate/n-hexane) to obtain Compound 19a (829 mg, 29%) as a white solid.

Aufarbeitung

  1. temperaturewhile refluxing
  2. temperatureunder heating for 10 hours
  3. temperatureto cool
  4. distillationthe solvent was distilled off
  5. customThe obtained residue was purified by column chromatography (6.25% ethyl acetate/n-hexane)

Quellen und Nachweise

ORD-Eintrag
ord-d698436e2133487c8add22e095a73a7e
Quelldatensatz
uspto-grants-2010_12
Patentnummer
US07855300B2

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