Ethyl 4-[[3,5-bis(trimethylsilyl)benzoyl]amino]cinnamate → Ethyl 3-[4-[[3,5-bis(trimethylsilyl)benzoyl]amino]phenyl]propanoate

HRID 2265117Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2265117
[CH3:1][Si:2]([CH3:30])([CH3:29])[C:3]1[CH:4]=[C:5]([CH:22]=[C:23]([Si:25]([CH3:28])([CH3:27])[CH3:26])[CH:24]=1)[C:6]([NH:8][C:9]1[CH:21]=[CH:20][C:12]([CH:13]=[CH:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:11][CH:10]=1)=[O:7].[H][H]>CO.C(OCC)(=O)C>[CH3:28][Si:25]([CH3:26])([CH3:27])[C:23]1[CH:22]=[C:5]([CH:4]=[C:3]([Si:2]([CH3:1])([CH3:30])[CH3:29])[CH:24]=1)[C:6]([NH:8][C:9]1[CH:10]=[CH:11][C:12]([CH2:13][CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:20][CH:21]=1)=[O:7]

Komponenten

5

Edukt 2

HCID 68487569Ethyl 4-[[3,5-bis(trimethylsilyl)benzoyl]amino]cinnamateHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 68485079Ethyl 3-[4-[[3,5-bis(trimethylsilyl)benzoyl]amino]phenyl]propanoateAusbeute 99,5 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

Compound 17a (150 mg) was dissolved in methanol (35 ml) and ethyl acetate (35 ml). The obtained mixture was stirred for 30 minutes in a hydrogen atmosphere. After the reaction was over, the obtained reaction mixture was filtered through Cerite, and then washed with methanol. The solvent was distilled off from the filtrate, and the obtained residue was dried. Thus, Compound 20a (150 mg, quant.) was obtained as a white solid.

Aufarbeitung

  1. customthe obtained reaction mixture
  2. filtrationwas filtered through Cerite
  3. washwashed with methanol
  4. distillationThe solvent was distilled off from the filtrate
  5. customthe obtained residue was dried

Quellen und Nachweise

ORD-Eintrag
ord-e5f4e8f7fcce40cbad5658a312266c25
Quelldatensatz
uspto-grants-2010_12
Patentnummer
US07855300B2

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