Chlorosulfonic acid → [2-(4-Fluorophenoxy)phenyl]sulfonyl chloride

HRID 2265876Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2265876
[Cl:1][S:2]([OH:5])(=O)=[O:3].[F:6][C:7]1[CH:19]=[CH:18][C:10]([O:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:9][CH:8]=1>ClCCl>[F:6][C:7]1[CH:19]=[CH:18][C:10]([O:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[S:2]([Cl:1])(=[O:5])=[O:3])=[CH:9][CH:8]=1

Komponenten

4

Edukt 2

HCID 24638Chlorosulfonic acidHCID 676141-Fluoro-4-phenoxybenzene

Produkt 1

HCID 5187142[2-(4-Fluorophenoxy)phenyl]sulfonyl chloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

16.1 g (0.138 mol) of chlorosulfonic acid are slowly added dropwise to a solution of 13.05 g of 4-fluorophenoxybenzene (0.069 mol) cooled to 0° C. After the addition is complete, the mixture is stirred at room temperature for a further 4 hours. For work up, 50 ml of dichloromethane are added, and the mixture is washed once with H2O. The aqueous phase is separated off and extracted twice more with 50 ml of dichloromethane each time. The combined organic phases are dried with MgSO4 and concentrated, resulting in the title compound as a colorless solid. Yield: 11.03 g; 60%.

Aufarbeitung

  1. additionAfter the addition
  2. washthe mixture is washed once with H2O
  3. customThe aqueous phase is separated off
  4. extractionextracted twice more with 50 ml of dichloromethane each time
  5. dry with materialThe combined organic phases are dried with MgSO4
  6. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-eb20f46957c549419a0abe64f464ee33
Quelldatensatz
uspto-grants-2010_12
Patentnummer
US07858619B2

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