3-(2-Chloro-6-trifluoromethyl-pyridin-3-yl)-acrylic acid → 3-(2-Chloro-6-trifluoromethyl-pyridin-3-yl)-N-(3-ethynyl-5-fluoro-4-methanesulfonylamino-benzyl)-acrylamide

HRID 2265961

Reaktionsgleichung

Reaktionsgleichung von HRID 2265961
Cl.[NH2:2][CH2:3][C:4]1[CH:9]=[C:8]([F:10])[C:7]([NH:11][S:12]([CH3:15])(=[O:14])=[O:13])=[C:6]([C:16]#[CH:17])[CH:5]=1.[Cl:18][C:19]1[C:24]([CH:25]=[CH:26][C:27](O)=[O:28])=[CH:23][CH:22]=[C:21]([C:30]([F:33])([F:32])[F:31])[N:20]=1>>[Cl:18][C:19]1[C:24]([CH:25]=[CH:26][C:27]([NH:2][CH2:3][C:4]2[CH:9]=[C:8]([F:10])[C:7]([NH:11][S:12]([CH3:15])(=[O:14])=[O:13])=[C:6]([C:16]#[CH:17])[CH:5]=2)=[O:28])=[CH:23][CH:22]=[C:21]([C:30]([F:31])([F:32])[F:33])[N:20]=1

Komponenten

3

Edukt 2

HCID 723356323-(2-Chloro-6-trifluoromethyl-pyridin-3-yl)-acrylic acidHCID 86625519HCID 86625519, Verbindung

Produkt 1

HCID 743823853-(2-Chloro-6-trifluoromethyl-pyridin-3-yl)-N-(3-ethynyl-5-fluoro-4-methanesulfonylamino-benzyl)-acrylamideAusbeute 90 %

Versuchsvorschrift

N-(4-Aminomethyl-2-ethynyl-6-fluoro-phenyl)-methanesulfonamide HCl salt (228 mg, 0.795 mmol) was reacted with 3-(2-chloro-6-trifluoromethyl-pyridin-3-yl)-acrylic acid (200 mg, 0.795 mmol) to give the title compound (340 mg, 90%).

Quellen und Nachweise

ORD-Eintrag
ord-b104e79672b449e2a58db342b54ae101
Quelldatensatz
uspto-grants-2010_12
Patentnummer
US07858621B2

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