Propyl mercaptan → 3-(2-Propylthio-6-trifluoromethyl-pyridin-3-yl)-acrylic acid

HRID 2266028

Reaktionsgleichung

Reaktionsgleichung von HRID 2266028
Cl[C:2]1[C:7]([CH:8]=[CH:9][C:10]([OH:12])=[O:11])=[CH:6][CH:5]=[C:4]([C:13]([F:16])([F:15])[F:14])[N:3]=1.[CH2:17]([SH:20])[CH2:18][CH3:19].[H-].[Na+]>>[CH2:17]([S:20][C:2]1[C:7]([CH:8]=[CH:9][C:10]([OH:12])=[O:11])=[CH:6][CH:5]=[C:4]([C:13]([F:16])([F:15])[F:14])[N:3]=1)[CH2:18][CH3:19]

Komponenten

4

Edukt 3

HCID 7848Propyl mercaptanHCID 24758Sodium hydrideHCID 723356323-(2-Chloro-6-trifluoromethyl-pyridin-3-yl)-acrylic acid

Produkt 1

HCID 687820003-(2-Propylthio-6-trifluoromethyl-pyridin-3-yl)-acrylic acidAusbeute 40,9 %

Versuchsvorschrift

3-(2-Chloro-6-trifluoromethyl-pyridin-3-yl)-acrylic acid (243 mg, 0.966 mmol) was reacted with propanthiol (229 mg, 3.01 mmol) and sodium hydride (145 mg, 3.62 mmol) to afford title compound (115 mg) after purification by column chromatography (Hex EtOAc=2/3).

Quellen und Nachweise

ORD-Eintrag
ord-e2fdece70e554f36b9f05f95e76a3e8d
Quelldatensatz
uspto-grants-2010_12
Patentnummer
US07858621B2

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