Chlorosulfonic acid → 4-(2-((5-Chloro-2-methoxyphenyl)formamido)ethyl)benzene-1-sulfonyl chloride

HRID 2266402

Reaktionsgleichung

Reaktionsgleichung von HRID 2266402
[Cl:1][S:2]([OH:5])(=O)=[O:3].[Cl:6][C:7]1[CH:8]=[CH:9][C:10]([O:24][CH3:25])=[C:11]([CH:23]=1)[C:12]([NH:14][CH2:15][CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=[O:13]>ClCCl>[Cl:6][C:7]1[CH:8]=[CH:9][C:10]([O:24][CH3:25])=[C:11]([CH:23]=1)[C:12]([NH:14][CH2:15][CH2:16][C:17]1[CH:18]=[CH:19][C:20]([S:2]([Cl:1])(=[O:5])=[O:3])=[CH:21][CH:22]=1)=[O:13]

Komponenten

4

Edukt 2

HCID 24638Chlorosulfonic acidHCID 1185755-chloro-2-methoxy-N-(2-phenylethyl)benzamide

Produkt 1

HCID 44545764-(2-((5-Chloro-2-methoxyphenyl)formamido)ethyl)benzene-1-sulfonyl chloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

4.5 ml chlorosulfonic acid were added in one portion to 6.5 g 5-Chloro-2-methoxy-N-phenethyl-benzamide. The reaction mixture was stirred at room temperature for one hour, then 100 ml dichloromethane were added and the reaction mixture was poured on ice water. The organic layer was separated washed twice with 50 ml brine and then dried over MgSO4. The solvent was removed in vacuo to obtain 5.53 g 4-[2-(5-Chloro-2-methoxy-benzoylamino)-ethyl]-benzenesulfonyl chloride.

Aufarbeitung

  1. additionthe reaction mixture was poured on ice water
  2. customThe organic layer was separated
  3. washwashed twice with 50 ml brine
  4. dry with materialdried over MgSO4
  5. customThe solvent was removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-0c300a18388c493fb0bf603caca3c355
Quelldatensatz
uspto-grants-2010_12
Patentnummer
US07858647B2

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