Sodium Hydroxide → 1-(3-Bromophenyl)-1H-imidazole-4-carboxylic acid

HRID 2266407Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2266407
C([O:3][C:4]([C:6]1[N:7]=[CH:8][N:9]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([Br:17])[CH:12]=2)[CH:10]=1)=[O:5])C.[OH-].[Na+]>CO>[Br:17][C:13]1[CH:12]=[C:11]([N:9]2[CH:10]=[C:6]([C:4]([OH:5])=[O:3])[N:7]=[CH:8]2)[CH:16]=[CH:15][CH:14]=1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 161287541-(3-Bromo-phenyl)-1H-imidazole-4-carboxylic acid ethyl ester

Produkt 1

HCID 234449541-(3-Bromophenyl)-1H-imidazole-4-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Reaktionsbedingungen

Temperatur
40 °C

Versuchsvorschrift

To a solution of 3 (0.5 g, 1.7 mmol) in methanol (25 mL) was added aqueous NaOH (2M; 4.3 mL) and the reaction mixture was stirred at 40° C. for 0.5 h. Methanol was removed in vacuo and the water layer acidified and extracted with ethyl acetate, dried, filtered and evaporated to dryness. The crude compound was used as such for the next step.

Aufarbeitung

  1. customMethanol was removed in vacuo
  2. extractionextracted with ethyl acetate
  3. customdried
  4. filtrationfiltered
  5. customevaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-a05c09233d764bc3a16937b3089a19dd
Quelldatensatz
uspto-grants-2010_12
Patentnummer
US07858649B2

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