p-Toluenesulfonic acid → 3-(4-Chlorobenzyl)-2,4,7-trimethylquinolin-5-ol

HRID 2266430Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2266430
[NH2:1][C:2]1[CH:3]=[C:4]([OH:9])[CH:5]=[C:6]([CH3:8])[CH:7]=1.[Cl:10][C:11]1[CH:24]=[CH:23][C:14]([CH2:15][CH:16]([C:20](=O)[CH3:21])[C:17](=O)[CH3:18])=[CH:13][CH:12]=1.C1(C)C=CC(S(O)(=O)=O)=CC=1>>[Cl:10][C:11]1[CH:24]=[CH:23][C:14]([CH2:15][C:16]2[C:20]([CH3:21])=[N:1][C:2]3[CH:7]=[C:6]([CH3:8])[CH:5]=[C:4]([OH:9])[C:3]=3[C:17]=2[CH3:18])=[CH:13][CH:12]=1

Komponenten

4

Edukt 3

HCID 6101p-Toluenesulfonic acidHCID 14888033-[(4-Chlorophenyl)methyl]pentane-2,4-dioneHCID 30186673-Amino-5-methylphenol

Produkt 1

HCID 1363463303-(4-Chlorobenzyl)-2,4,7-trimethylquinolin-5-ol

Reaktionsbedingungen

Temperatur
160 °C

Versuchsvorschrift

A mixture of 3-amino-5-methylphenol (1.0 g), 3-(4-chlorobenzyl)pentane-2,4-dione (1.7 g) and toluene-4-sulfonic acid (0.30 g) was heated at 160° C. under nitrogen for 3 hours. The mixture was cooled to room temperature and the residue triturated with methanol to give title compound, 1.5 g.

Aufarbeitung

  1. temperatureThe mixture was cooled to room temperature
  2. customthe residue triturated with methanol

Quellen und Nachweise

ORD-Eintrag
ord-f1acf58de28a45b6a0f12da71a887aaa
Quelldatensatz
uspto-grants-2010_12
Patentnummer
US07858640B2

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