Methanol → Methyl p-aminosalicylate

HRID 226801

Reaktionsgleichung

Reaktionsgleichung von HRID 226801
[NH2:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[C:4]([OH:11])[CH:3]=1.[CH3:12]O>>[OH:11][C:4]1[CH:3]=[C:2]([CH:10]=[CH:9][C:5]=1[C:6]([O:8][CH3:12])=[O:7])[NH2:1]

Komponenten

3

Edukt 2

HCID 887MethanolHCID 46494-Aminosalicylic Acid

Produkt 1

HCID 77787Methyl p-aminosalicylate

Versuchsvorschrift

A solution of 4-amino-2-hydroxybenzoic acid (1 g, 6.5 mmol) in MeOH (15 mL) and concentrated sulfonic acid (1 mL) was refluxed overnight. The reaction mixture was quenched with NaHCO3 aqueous solution (60 mL) and EtOAc (60 mL). The organic layer was separated, dried, evaporated to give 3-hydroxy-4-methoxycarbonylaniline.

Aufarbeitung

  1. customThe reaction mixture was quenched with NaHCO3 aqueous solution (60 mL) and EtOAc (60 mL)
  2. customThe organic layer was separated
  3. customdried
  4. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-2e59af37f17b4ef4879d0356c4247e47
Quelldatensatz
uspto-grants-2009_07
Patentnummer
US07557210B2

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