N-(1-ethyl-1-phenylpropyl)acrylamide → 3-[4-(cyanomethyl)imidazol-1-yl]-N-(1-ethyl-1-phenylpropyl)propionamide
Reaktionsgleichung
[CH2:1]([C:3]([NH:12][C:13](=[O:16])[CH:14]=[CH2:15])([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[CH2:4][CH3:5])[CH3:2].[C:17]([CH2:19][C:20]1[N:21]=[CH:22][NH:23][CH:24]=1)#[N:18]>O1CCOCC1>[C:17]([CH2:19][C:20]1[N:21]=[CH:22][N:23]([CH2:15][CH2:14][C:13]([NH:12][C:3]([CH2:4][CH3:5])([C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=2)[CH2:1][CH3:2])=[O:16])[CH:24]=1)#[N:18]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
In a similar manner to Example 24, N-(1-ethyl-1phenylpropyl)acrylamide (6.1 g) and 4-cyanomethylimidazole (3.0 g, Sigma Chemicals) were reacted in 1,4-dioxane (60 ml) in the presence of Triton B (0.8 ml) to give 3-[4-(cyanomethyl)imidazol-1-yl]—N-(1-ethyl-1phenylpropyl)propionamide, m.p. 121-122° C.