Ammonia → 1-(Pyridin-2-yl)piperidin-4-one

HRID 2268423

Reaktionsgleichung

Reaktionsgleichung von HRID 2268423
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[N:7]1[CH2:16][CH2:15][C:10]2(OCC[O:11]2)[CH2:9][CH2:8]1.S(=O)(=O)(O)O.N>>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[N:7]1[CH2:8][CH2:9][C:10](=[O:11])[CH2:15][CH2:16]1

Komponenten

4

Edukt 3

HCID 222AmmoniaHCID 1118Sulfuric AcidHCID 120337658-(2-Pyridinyl)-1,4-dioxa-8-azaspiro[4.5]decane

Produkt 1

HCID 183483911-(Pyridin-2-yl)piperidin-4-oneAusbeute 83,4 %

Versuchsvorschrift

A solution of 8-(2-pyridinyl)-1,4-dioxa-8-azaspiro[4.5]decane (23 g, 0.1 mol) (preparation 36) in 10% w/v sulphuric acid was stirred at room temperature for 8 hr. The reaction mixture was cooled in ice and then the solution adjusted to pH>7 with 0.88 ammonia. The solution was extracted with diethyl ether and the solvent removed from the organic extracts under reduced pressure to give the title compound (14.7 g) as an oil.

Aufarbeitung

  1. temperatureThe reaction mixture was cooled in ice
  2. extractionThe solution was extracted with diethyl ether
  3. customthe solvent removed from the organic extracts under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-334b9e7078ef42b789688bc9d55a5949
Quelldatensatz
uspto-grants-2001_12
Patentnummer
US06326359B1

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