Diethylamine → 3-benzyloxy-N,N-diethyl-4-methoxy-benzamide

HRID 2268867

Reaktionsgleichung

Reaktionsgleichung von HRID 2268867
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH:15]=[CH:16][C:17]=1[O:18][CH3:19])[C:12](Cl)=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:20]([NH:22][CH2:23][CH3:24])[CH3:21]>C(Cl)Cl>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH:15]=[CH:16][C:17]=1[O:18][CH3:19])[C:12]([N:22]([CH2:23][CH3:24])[CH2:20][CH3:21])=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

4

Edukt 2

HCID 8021DiethylamineHCID 109677953-Benzyloxy-4-methoxybenzoyl chloride

Produkt 1

HCID 185048043-benzyloxy-N,N-diethyl-4-methoxy-benzamideAusbeute 95 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

A solution of 3-benzyloxy-4-methoxy-benzoyl chloride (35.01 g, 0.127 mole), prepared as described in example 54, in CH2Cl2 (200 ml) was dropwise added at 5-10° C. with diethylamine (131 ml, 92.54 g, 1.27 mole) in CH2Cl2 (130 ml). The mixture was evaporated to dryness, dissolved in ethyl acetate, washed with water, 2% KHSO4, water again and NaHCO3, anhydrified over Na2SO4 and brought to dryness. The residue was taken up in petrolatum (250 ml) to give 37.65 g of the title compound (yield: 95%)

Aufarbeitung

  1. customThe mixture was evaporated to dryness
  2. dissolutiondissolved in ethyl acetate
  3. washwashed with water, 2% KHSO4, water again

Quellen und Nachweise

ORD-Eintrag
ord-766d7df6bd9c434bb383a91e1f55fd4e
Quelldatensatz
uspto-grants-2001_12
Patentnummer
US06329370B1

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