(4-Methoxyphenyl)(3-nitrophenyl)methanone → N-[(R)-1-(3-Fluorophenyl)ethyl]-N-[(4-methoxyphenyl)-(3-nitrophenyl)methyl]amine
Reaktionsgleichung
[N+:1]([C:4]1[CH:5]=[C:6]([C:10]([C:12]2[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=2)=O)[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].Cl.[F:21][C:22]1[CH:23]=[C:24]([C@H:28]([NH2:30])[CH3:29])[CH:25]=[CH:26][CH:27]=1>>[F:21][C:22]1[CH:23]=[C:24]([C@H:28]([NH:30][CH:10]([C:12]2[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=2)[C:6]2[CH:7]=[CH:8][CH:9]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=2)[CH3:29])[CH:25]=[CH:26][CH:27]=1Komponenten
3
Versuchsvorschrift
Following a similar procedure to that described in Example (1a), 11.16 g of 4-methoxyphenyl 3-nitrophenyl ketone and 7.62 g of (R)-1-(3-fluorophenyl)ethylamine hydrochloride were reacted, to obtain 15.11 of the title compound as a pale yellow oil.
Aufarbeitung
- customwere reacted