HCID 178500760, Verbindung → 3-(3,4-dimethylbenzoyl)-6-fluoroquinolin-4(1H)-one

HRID 226962

Reaktionsgleichung

Reaktionsgleichung von HRID 226962
CO[C:3](=[O:24])[C:4]([C:14](=[O:23])[C:15]1[CH:20]=[CH:19][C:18]([CH3:21])=[C:17]([CH3:22])[CH:16]=1)=[CH:5][NH:6][C:7]1[CH:12]=[CH:11][C:10]([F:13])=[CH:9][CH:8]=1>C1(OC2C=CC=CC=2)C=CC=CC=1.CCCCCC>[CH3:22][C:17]1[CH:16]=[C:15]([CH:20]=[CH:19][C:18]=1[CH3:21])[C:14]([C:4]1[C:3](=[O:24])[C:8]2[C:7](=[CH:12][CH:11]=[C:10]([F:13])[CH:9]=2)[NH:6][CH:5]=1)=[O:23]

Komponenten

4

Edukt 1

HCID 178500760HCID 178500760, Verbindung

Produkt 1

HCID 46065703-(3,4-dimethylbenzoyl)-6-fluoroquinolin-4(1H)-oneAusbeute 66,1 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 7583Diphenyl EtherLösungsmittelHCID 8058HexaneLösungsmittel

Versuchsvorschrift

0.691 g (2.11 mmol) of 2-(3,4-Dimethyl-benzoyl)-3-(4-fluoro-phenylamino)-acrylic acid methyl ester 2g was dissolved in 30 mL of diphenyl ether and the resultant solution was heated at 250° C. After 2.5 h the solution was cooled to room temperature and diluted with 50 mL of hexane. The crude product precipitated out of solution and was isolated by filtration. The crude product was further washed with hexane to yield 0.412 g of 3-(3,4-dimethyl-benzoyl)-6-fluoro-1H-quinolin-4-one 3j as a brown solid.

Aufarbeitung

  1. customThe crude product precipitated out of solution
  2. customwas isolated by filtration
  3. washThe crude product was further washed with hexane

Quellen und Nachweise

ORD-Eintrag
ord-07f7734ea7a1418e94850b8843af144c
Quelldatensatz
uspto-grants-2009_07
Patentnummer
US07557213B2

Verknüpfte Notizen

Wird geladen…