Hexane → HCID 86613649, Verbindung

HRID 226985

Reaktionsgleichung

Reaktionsgleichung von HRID 226985
C(O[C:4](=[O:20])[C:5](=[CH:11][NH:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15](C)[N:14]=1)[C:6]([O:8][CH2:9][CH3:10])=[O:7])C.[CH3:21]CCCCC>C1(OC2C=CC=CC=2)C=CC=CC=1>[CH2:9]([O:8][C:6]([C:5]1[C:4](=[O:20])[C:18]2[C:13](=[N:14][CH:15]=[CH:16][CH:17]=2)[N:12]([CH3:21])[CH:11]=1)=[O:7])[CH3:10]

Komponenten

4

Edukt 2

HCID 8058HexaneHCID 83264Diethyl [[(6-methyl-2-pyridyl)amino]methylene]malonate

Produkt 1

HCID 86613649HCID 86613649, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 7583Diphenyl EtherLösungsmittel

Reaktionsbedingungen

Temperatur
250 °C

Versuchsvorschrift

21.8 g (3.61 mmol) of 2-[(6-Methyl-pyridin-2-ylamino)-methylene]-malonic acid diethyl ester was dissolved in 300 mL of diphenyl ether and the solution was heated at 250° C. After 2.5 h the solution was cooled to rt and 50 mL of hexane was added. The mixture was filtered and the solid washed with hexane to yield 18.5 g of -Methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester as a brown solid.

Aufarbeitung

  1. temperatureAfter 2.5 h the solution was cooled to rt
  2. filtrationThe mixture was filtered
  3. washthe solid washed with hexane

Quellen und Nachweise

ORD-Eintrag
ord-d1b60e42c46b4bb7ade946be2e5a443f
Quelldatensatz
uspto-grants-2009_07
Patentnummer
US07557213B2

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