HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Sodium hydride → 7-(3,4-dimethyl-benzoyl)-5-pyridin-2-ylmethyl-5H-[1,3]dioxolo[4,5-g]quinolin-8-one
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Sodium hydride | HCID 24758 | — |
| Edukt | 2-(Bromomethyl)pyridine hydrobromide | HCID 2734720 | — |
| Edukt | 7-(3,4-dimethyl-benzoyl)-5H-[1,3]dioxolo[4,5-g]quinolin-8-one | HCID 53337338 | — |
| Lösungsmittel | Dimethylformamide | HCID 6228 | — |
| Produkt | 7-(3,4-dimethyl-benzoyl)-5-pyridin-2-ylmethyl-5H-[1,3]dioxolo[4,5-g]quinolin-8-one | HCID 16730851 | — |
Reaktionsschritte
Experimental conditions analogous to those described for Step 3 of Example 1, from 71 mg (0.22 mmol) of 7-(3,4-dimethyl-benzoyl)-5H-[1,3]dioxolo[4,5-g]quinolin-8-one, 23 mg of 60% sodium hydride, 72 mg of 2-bromomethylpyridine hydrobromide and 1.3 mL of N,N-dimethylformamide. Yield: 75 mg of a white solid: LC-MSD, m/z for C25H20N2O4 [M+H]+=413.5; HPLC retention time: 2.1 min.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07557213B2 |
| Quelldatensatz | uspto-grants-2009_07 |
| ORD ID | ord-1da046d7981e42fb9d0711267a276849 |
| Quellennotiz | uspto-grants-2009_07 |