HCID 11449562, Verbindung → HCID 72806257, Verbindung
Reaktionsgleichung
[CH3:1][N:2]([CH3:22])[C:3]([CH2:5][CH2:6][CH2:7][C:8]#[C:9][C:10]1[CH:11]=[C:12]([CH:19]=[CH:20][CH:21]=1)[C:13]([NH:15][CH2:16][CH2:17][F:18])=[O:14])=[O:4]>[Ni]>[CH3:22][N:2]([CH3:1])[C:3]([CH2:5][CH2:6][CH2:7][CH:8]=[CH:9][C:10]1[CH:11]=[C:12]([CH:19]=[CH:20][CH:21]=1)[C:13]([NH:15][CH2:16][CH2:17][F:18])=[O:14])=[O:4]Komponenten
3
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
Hydrogenation of 3-(5-dimethylcarbamoyl-pent-1-ynyl)-N-(2-fluoro-ethyl)benzamide (26) (0.040 g, 0.13 mmol) using BER/Ni catalyst gave 40% 28, and 55% of starting material. The mixture was separated by reverse-phase HPLC chromatography (30% acetonitrile/70% water 20 min isocratic program) to give 3-(5-dimethylcarbamoyl-pent-1-enyl)-N-(2-fluoro-ethyl)-benzamide 28 (5 mg).
Quellen und Nachweise
- ORD-Eintrag
- ord-c9b2cf240a3e405da87a91674eaf7eed
- Quelldatensatz