1-(Bromomethyl)-3-(trifluoromethyl)benzene → 3-(4-Methoxy-3-methyl-benzoyl)-1-(3-trifluoromethyl-benzyl)-1H-[1,8]naphthyridin-4-one
Reaktionsgleichung
[CH3:1][O:2][C:3]1[CH:21]=[CH:20][C:6]([C:7]([C:9]2[C:18](=[O:19])[C:17]3[C:12](=[N:13][CH:14]=[CH:15][CH:16]=3)[NH:11][CH:10]=2)=[O:8])=[CH:5][C:4]=1[CH3:22].Br[CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[C:27]([C:31]([F:34])([F:33])[F:32])[CH:26]=1>>[CH3:1][O:2][C:3]1[CH:21]=[CH:20][C:6]([C:7]([C:9]2[C:18](=[O:19])[C:17]3[C:12](=[N:13][CH:14]=[CH:15][CH:16]=3)[N:11]([CH2:24][C:25]3[CH:30]=[CH:29][CH:28]=[C:27]([C:31]([F:32])([F:33])[F:34])[CH:26]=3)[CH:10]=2)=[O:8])=[CH:5][C:4]=1[CH3:22]Komponenten
3
Versuchsvorschrift
Experimental conditions analogous to those described for Step 3 of Example 1, from 50 mg (0.17 mmol) of 3-(4-Methoxy-3-methyl-benzoyl)-1H-[1,8]naphthyridin-4-one, and 1-Bromomethyl-3-trifluoromethyl-benzene 53 mg (0.22 mmol), to give 12 mg of desired compound. LCMS (M+H)+: 453.1.
Quellen und Nachweise
- ORD-Eintrag