Hydrochloric Acid → HCID 70676330, Verbindung

HRID 2271497Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2271497
Cl.[Cl:2][C:3]1[CH:4]=[C:5]([CH:10]([O:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH:11]2[CH2:14][N:13](C(OC(C)(C)C)=O)[CH2:12]2)[CH:6]=[CH:7][C:8]=1[Cl:9]>CO>[ClH:2].[Cl:2][C:3]1[CH:4]=[C:5]([CH:10]([O:22][C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH:11]2[CH2:14][NH:13][CH2:12]2)[CH:6]=[CH:7][C:8]=1[Cl:9]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 70676150HCID 70676150, Verbindung

Produkt 1

HCID 70676330HCID 70676330, VerbindungAusbeute 97 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

1N HCl (3 mL) was added to 10 mL of tertiary butyl 3-((3,4-dichlorophenyl)(phenoxy)methyl)azetidine-1-carboxylate (150 mg, 0.352 mmol) dissolved in a methanol solution, and heated to reflux at 60° C. for one day. Thereafter, the solvent of the reaction mixture was removed by reduced pressure evaporation to obtain the title compound.

Aufarbeitung

  1. temperatureheated
  2. customThereafter, the solvent of the reaction mixture was removed by reduced pressure evaporation

Quellen und Nachweise

ORD-Eintrag
ord-93bc20a08d9041a0b7ad8d0f4530eab1
Quelldatensatz
uspto-grants-2015_09
Patentnummer
US09120771B2

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