Triethylamine → (S)-1-Boc-3-methylpiperazine

HRID 22720Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 22720
[C:1]([O:5][C:6]([N:8]1[CH2:12][C:11](=O)[N:10](C)[CH:9]1[C:15]([CH3:18])(C)C)=[O:7])([CH3:4])([CH3:3])[CH3:2].C[C@H]1CNCCN1.C(N(CC)CC)C>C(Cl)(Cl)Cl>[CH3:18][C@@H:15]1[NH:10][CH2:11][CH2:12][N:8]([C:6]([O:5][C:1]([CH3:2])([CH3:3])[CH3:4])=[O:7])[CH2:9]1

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 546472(R)-1-Boc-2-tert-butyl-3-methyl-4-imidazolidinoneHCID 27342192-Methylpiperazine, (S)-

Produkt 1

HCID 7023035(S)-1-Boc-3-methylpiperazine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel2×

Versuchsvorschrift

1-(tert-butoxycarbonyl)-2-tert-butyl-3-methyl-4-imidazolidinone (2 g, 8.3 mmol) (BOC—ON), in chloroform (15 ml), was added to (2S)-2-methylpiperazine (5 g, 50 mmol), a compound of formula (A), in a mixture of triethylamine (1.25 g, 12.5 mmol) and chloroform. The mixture was stirred for about 15 hours and then washed with water, the solvent removed in vacuo. The residue was purified by column chromatography, to give tert-butyl (3S)-3-methylpiperazinecarboxylate, a compound of formula (B).

Aufarbeitung

  1. washwashed with water
  2. customthe solvent removed in vacuo
  3. customThe residue was purified by column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-182168b7a48648cf91d58092eaab5d2c
Quelldatensatz
uspto-grants-2005_02
Patentnummer
US06849632B2

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