1,2-Dibromoethane → 1,4-Dibromo-2-(2-bromoethoxy)benzene

Temperatur

80 °C

A mixture of 2,5-dibromophenol (134) (1.26 g, 5 mmol) and 1,2-dibromoethane (135) (431 μl, 5 mmol) in 5 ml 1N NaOH was stirred at 80° C. for 40 h. After cooling down, the reaction mixture was extracted with diethyl ether. Org. phase was washed with 1 N NaOH and brine subsequently. Org. phase was dried over sodium sulfate concentrated to give 922 mg (yield 51%, purity ca 90%) 1,4-dibromo-2-(2-bromoethoxy)benzene (136) as orange-red oil which was used directly for further reaction without purification.

1. temperatureAfter cooling down
2. extractionthe reaction mixture was extracted with diethyl ether
3. washphase was washed with 1 N NaOH and brine subsequently
4. dry with materialphase was dried over sodium sulfate
5. concentrationconcentrated

ORD-Eintrag

ord-ff981cb3fd21463586053632b956652d

Quelldatensatz

uspto-grants-2015_09

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US09120751B2