Boron tribromide → 2-(2,4-Dichlorophenyl)benzoxazol-5-ol

HRID 22725

Reaktionsgleichung

Reaktionsgleichung von HRID 22725
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[O:10][C:11]2[CH:17]=[CH:16][C:15]([O:18]C)=[CH:14][C:12]=2[N:13]=1.B(Br)(Br)Br>ClCCl>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[O:10][C:11]2[CH:17]=[CH:16][C:15]([OH:18])=[CH:14][C:12]=2[N:13]=1

Komponenten

4

Edukt 2

HCID 25134Boron tribromideHCID 219116842-(2,4-Dichlorophenyl)-5-methoxybenzoxazole

Produkt 1

HCID 219117282-(2,4-Dichlorophenyl)benzoxazol-5-ol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

2-(2,4-dichlorophenyl)-5-methoxybenzoxazole (0.5 g, 1.7 mmol) was dissolved in 25 mL of dichloromethane. To the solution was added BBr3 (8 mmol) and the mixture was stirred at room temperature for 48 hours. The mixture was then diluted with 25 mL dichloromethane, and washed sequentially with saturated NaHCO3 (2×25 mL) and brine. The organic layer was separated, dried over MgSO4 and filtered. The solvent was removed, to provide 2-(2,4-dichlorophenyl)benzoxazol-5-ol, a compound of formula (g), which was purified using flash chromatography.

Aufarbeitung

  1. washwashed sequentially with saturated NaHCO3 (2×25 mL) and brine
  2. customThe organic layer was separated
  3. dry with materialdried over MgSO4
  4. filtrationfiltered
  5. customThe solvent was removed

Quellen und Nachweise

ORD-Eintrag
ord-482f9b27ae834db0a04f5d25e333abc3
Quelldatensatz
uspto-grants-2005_02
Patentnummer
US06849632B2

Verknüpfte Notizen

Wird geladen…