tert-Butyl (4-hydroxynaphthalen-1-yl)carbamate → Tert-butyl 4-(2-amino-3-nitropyridin-4-yloxy)naphthalen-1-ylcarbamate

HRID 2272682Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2272682
[OH:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([NH:12][C:13](=[O:19])[O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[CH:4][CH:3]=1.[NH2:20][C:21]1[C:26]([N+:27]([O-:29])=[O:28])=[C:25](OC2C=CC(NC(=O)OC(C)(C)C)=C(F)C=2)[CH:24]=[CH:23][N:22]=1>>[C:15]([O:14][C:13](=[O:19])[NH:12][C:5]1[C:6]2[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=2)[C:2]([O:1][C:25]2[CH:24]=[CH:23][N:22]=[C:21]([NH2:20])[C:26]=2[N+:27]([O-:29])=[O:28])=[CH:3][CH:4]=1)([CH3:16])([CH3:18])[CH3:17]

Komponenten

3

Edukt 2

HCID 10923237tert-Butyl (4-hydroxynaphthalen-1-yl)carbamateHCID 44185771Tert-butyl 4-(2-amino-3-nitropyridin-4-yloxy)-2-fluorophenylcarbamate

Produkt 1

HCID 44186165Tert-butyl 4-(2-amino-3-nitropyridin-4-yloxy)naphthalen-1-ylcarbamate

Versuchsvorschrift

The title compound was prepared from tert-butyl 4-hydroxynaphthalen-1-ylcarbamate (Regan, J. et al, J. Med. Chem., 2002, Vol. 45, No. 14, p. 2994) (3.9 g, 15 mmol) by the same method as described for compound (3a).

Quellen und Nachweise

ORD-Eintrag
ord-1f4e0fb09fe94fb7b17fcbcabf7ac208
Quelldatensatz
uspto-grants-2015_09
Patentnummer
US09120789B2

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