Potassium Carbonate → 5-[4-(6-fluoro-1H-indol-3-yl)-piperidin-1-ylmethyl]2-methoxybenzoic acid ethyl ester

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

A suspension containing 0.5 g (2.2 mmol) of 6-fluoro-3-piperidin-4-yl-1H-indole, 0.8 g (2.7 mmol) of 5-bromomethyl-2-methoxy-benzoic acid methyl ester and 0.6 g (4.3 mmol) of potassium carbonate in 10 ml of ethyl isobutylketone was heated at 90° C. for 16 hours. The inorganic solid was filtrated and the solvent was removed under reduced pressure. 0.91 g (97% of yield) of the expected product was obtained.

Herkunft & Nachweise