Hydrochloric Acid → 6-(5-Chloro-3-methyl-benzofuran-2-sulfonyl)-2H-pyridazin 2H-pyridazin-3-one

HRID 22732Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 22732
C[O:2][C:3]1[N:4]=[N:5][C:6]([S:9]([C:12]2[O:13][C:14]3[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][C:15]=3[C:16]=2[CH3:17])(=[O:11])=[O:10])=[CH:7][CH:8]=1.Cl>O1CCOCC1>[Cl:22][C:19]1[CH:20]=[CH:21][C:14]2[O:13][C:12]([S:9]([C:6]3[NH:5][NH:4][CH:3]=[CH:8][CH:7]=3)(=[O:10])=[O:11])=[C:16]([CH3:17])[C:15]=2[CH:18]=1.[N:5]1[NH:4][C:3](=[O:2])[CH:8]=[CH:7][CH:6]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 99458133-Methoxy-6-(5-chloro-3-methyl-benzofuran-2-sulfonyl)-pyridazine

Produkt 1

HCID 690493596-(5-Chloro-3-methyl-benzofuran-2-sulfonyl)-2H-pyridazin 2H-pyridazin-3-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

A mixture of 3-methoxy-6-(5-chloro-3-methyl-benzofuran-2-sulfonyl)-pyridazine (22.2 mmol, 7.5 g), conc. HCl (5 mL), and dioxane (50 mL) was heated at 100° C. for 2 hours. The reaction mixture was cooled and evaporated to dryness. Water (20 mL) was added to the residue. The resulting precipitate was collected and crystallized from ethanol to obtain the desired product: 6-(5-chloro-3-methyl-benzofuran-2-sulfonyl)-2H-pyridazin-2H-pyridazin-3-one (89%, 6.42 g).

Aufarbeitung

  1. temperatureThe reaction mixture was cooled
  2. customevaporated to dryness
  3. additionWater (20 mL) was added to the residue
  4. customThe resulting precipitate was collected
  5. customcrystallized from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-42e5f900598f452da816d1574fcbd6b2
Quelldatensatz
uspto-grants-2005_02
Patentnummer
US06849629B2

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