Thionyl Chloride → (Tetrahydro-2H-pyran-4-yl)acetyl chloride

Beteiligte Stoffe

Reaktionsschritte

A solution of tetrahydropyran-4-yl acetic acid (Combi-Blocks, Inc., 0.18 g, 1.2 mmol) in thionyl chloride (7 mL, 96 mmol, excess) was refluxed for 1 h then was cooled to ambient temperature and concentrated under reduced pressure. The residue was azeotroped twice with 10 mL of benzene to remove any remaining thionyl chloride. The resulting acid chloride was used without further purification.

Herkunft & Nachweise