Thionyl Chloride → (Tetrahydro-2H-pyran-4-yl)acetyl chloride

HRID 227402

Reaktionsgleichung

Reaktionsgleichung von HRID 227402
[O:1]1[CH2:6][CH2:5][CH:4]([CH2:7][C:8]([OH:10])=O)[CH2:3][CH2:2]1.S(Cl)([Cl:13])=O>>[O:1]1[CH2:6][CH2:5][CH:4]([CH2:7][C:8]([Cl:13])=[O:10])[CH2:3][CH2:2]1

Komponenten

3

Edukt 2

HCID 24386Thionyl ChlorideHCID 2773575Tetrahydropyran-4-ylacetic acid

Produkt 1

HCID 24229747(Tetrahydro-2H-pyran-4-yl)acetyl chloride

Versuchsvorschrift

A solution of tetrahydropyran-4-yl acetic acid (Combi-Blocks, Inc., 0.18 g, 1.2 mmol) in thionyl chloride (7 mL, 96 mmol, excess) was refluxed for 1 h then was cooled to ambient temperature and concentrated under reduced pressure. The residue was azeotroped twice with 10 mL of benzene to remove any remaining thionyl chloride. The resulting acid chloride was used without further purification.

Aufarbeitung

  1. concentrationconcentrated under reduced pressure
  2. customThe residue was azeotroped twice with 10 mL of benzene
  3. customto remove any remaining thionyl chloride
  4. customThe resulting acid chloride was used without further purification

Quellen und Nachweise

ORD-Eintrag
ord-3bf7479e775c4274a3a075fe423aef04
Quelldatensatz
uspto-grants-2009_07
Patentnummer
US07560481B2

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