N-bromobutanimide → 2-Amino-5-bromo-3-fluorobenzoic acid

HRID 2274220

Reaktionsgleichung

Reaktionsgleichung von HRID 2274220
[NH2:1][C:2]1[C:10]([F:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[Br:12]N1C(=O)CCC1=O>ClCCl>[NH2:1][C:2]1[C:10]([F:11])=[CH:9][C:8]([Br:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]

Komponenten

4

Edukt 2

HCID 67184N-bromobutanimideHCID 5864082-Amino-3-fluorobenzoic acid

Produkt 1

HCID 404245972-Amino-5-bromo-3-fluorobenzoic acidAusbeute 78 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A solution of 2-amino-3-fluorobenzoic acid (10.85 g, 70 mmol) in dichloromethane (175 mL) was added N-bromosuccinimide (12.46 g, 70 mmol), and the mixture was stirred at RT for 2 h. LCMS showed the reaction was completed. The precipitate was filtered and washed with dichloromethane (100 mL*3) to give the title compound (12.7 g, 78%) as a grey solid, which was directly used in the next step without further purification. MS (ES+) C7H5BrFNO2 requires: 233, 235. Found: 232, 234 [M−H]−.

Aufarbeitung

  1. filtrationThe precipitate was filtered
  2. washwashed with dichloromethane (100 mL*3)

Quellen und Nachweise

ORD-Eintrag
ord-6727622cad8a413ba3561916ceaa6d00
Quelldatensatz
uspto-grants-2015_09
Patentnummer
US09126951B2

Verknüpfte Notizen

Wird geladen…