(2-Amino-5-bromo-3-fluorophenyl)methanol → 2-Amino-5-bromo-3-fluorobenzaldehyde

HRID 2274222

Reaktionsgleichung

Reaktionsgleichung von HRID 2274222
[NH2:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([Br:9])=[CH:4][C:3]=1[CH2:10][OH:11]>ClCCl.[O-2].[Mn+2]>[NH2:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([Br:9])=[CH:4][C:3]=1[CH:10]=[O:11]

Komponenten

4

Edukt 1

HCID 54312525(2-Amino-5-bromo-3-fluorophenyl)methanol

Produkt 1

HCID 542514502-Amino-5-bromo-3-fluorobenzaldehydeAusbeute 85 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 160959Manganese oxideKatalysatorHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A mixture of (2-amino-5-bromo-3-fluorophenyl)methanol (13 g, 59.4 mmol) and manganese oxide (31 g, 356.4 mmol) in dichloromethane (400 mL) was stirred at RT overnight. TLC showed the starting material consumed completely. The solid was filtered off, and the filtrate was concentrated to give the title compound (11 g, 85%) as a light yellow solid, which was directly used in the next step without further purification.

Aufarbeitung

  1. customconsumed completely
  2. filtrationThe solid was filtered off
  3. concentrationthe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-3490db4bfe7d43eeabca51a7cc22fb8f
Quelldatensatz
uspto-grants-2015_09
Patentnummer
US09126951B2

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