Potassium Carbonate → 4-chloro-2-iodo O-crotyl phenol

HRID 22743

Reaktionsgleichung

Reaktionsgleichung von HRID 22743
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[C:4]([I:9])[CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[CH2:16](Br)[CH:17]=[CH:18][CH3:19]>CN(C=O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:16][CH:17]=[CH:18][CH3:19])=[C:4]([I:9])[CH:3]=1

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 1224142-Butene, 1-bromo-HCID 6202344-Chloro-2-iodophenol

Produkt 1

HCID 698740424-chloro-2-iodo O-crotyl phenolAusbeute 95,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

To a mixture of 4-chloro-2-iodo phenol (5.11 mmol, 1.3 g) in DMF (40 mL) and potassium carbonate (10 mmol, 1.4 g) was added crotyl bromide (10.2 mmol, 1.6 g) and the reaction mixture was stirred at room temperature for one hour. The reaction was quenched with H2O (100 mL) and extracted with EtOAc (2×50 mL). The EtOAc layer was collected, dried, filtered and the filtrate was evaporated to obtain 4-chloro-2-iodo O-crotyl phenol (94%, 1.5 g).

Aufarbeitung

  1. customThe reaction was quenched with H2O (100 mL)
  2. extractionextracted with EtOAc (2×50 mL)
  3. customThe EtOAc layer was collected
  4. customdried
  5. filtrationfiltered
  6. customthe filtrate was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-f5692c16398741cabed348cb70f8d640
Quelldatensatz
uspto-grants-2005_02
Patentnummer
US06849629B2

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