Sodium Hydroxide → Sodium 1-benzylpiperidine-4-carboxylate

HRID 2274485Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2274485
[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([C:14]([O:16]CC)=[O:15])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+:20]>C(O)C>[CH2:1]([N:8]1[CH2:9][CH2:10][CH:11]([C:14]([O-:16])=[O:15])[CH2:12][CH2:13]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1.[Na+:20]

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 90423Ethyl 1-benzylpiperidine-4-carboxylate

Produkt 1

HCID 67360726Sodium 1-benzylpiperidine-4-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To a solution consisting of ethyl 1-benzylpiperidine-4-carboxylate (500 mg, 2.02 mmol) in ethanol (10 mL) was added 1 N sodium hydroxide (2.02 mL, 2.02 mmol) and the reaction mixture was stirred at room temperature overnight. Most of the ethanol was removed under reduced pressure and stirring was continued for six hours. Toluene was added to remove most of the water by azeotrope and the material was dried under high vacuum overnight to provide the title intermediate as a white solid.

Aufarbeitung

  1. customMost of the ethanol was removed under reduced pressure
  2. stirringstirring
  3. waitwas continued for six hours
  4. additionToluene was added
  5. customto remove most of the water by azeotrope
  6. customthe material was dried under high vacuum overnight

Quellen und Nachweise

ORD-Eintrag
ord-623fa6dc7a264c3fb8ebbf9e90bdd645
Quelldatensatz
uspto-grants-2015_09
Patentnummer
US09126973B2

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