Hydrochloric Acid → (R)-(3-Aminopiperidin-1-yl)(7-methoxy-1-methyl-2-(1-(2,2,2-trifluoroethyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)-1H-benzo[d]imidazol-5-yl)methanone, hydrochloride

HRID 2275049Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2275049
[NH2:1][C@@H:2]1[CH2:7][CH2:6][CH2:5][N:4]([C:8]([C:10]2[CH:33]=[C:32]([O:34][CH3:35])[C:13]3[N:14]([CH3:31])[C:15]([C:17]4[N:25]([CH2:26][C:27]([F:30])([F:29])[F:28])[C:20]5=[N:21][CH:22]=[CH:23][CH:24]=[C:19]5[CH:18]=4)=[N:16][C:12]=3[CH:11]=2)=[O:9])[CH2:3]1.[ClH:36]>C(Cl)Cl>[ClH:36].[NH2:1][C@@H:2]1[CH2:7][CH2:6][CH2:5][N:4]([C:8]([C:10]2[CH:33]=[C:32]([O:34][CH3:35])[C:13]3[N:14]([CH3:31])[C:15]([C:17]4[N:25]([CH2:26][C:27]([F:30])([F:29])[F:28])[C:20]5=[N:21][CH:22]=[CH:23][CH:24]=[C:19]5[CH:18]=4)=[N:16][C:12]=3[CH:11]=2)=[O:9])[CH2:3]1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 73052940(R)-(3-Aminopiperidin-1-yl)(7-methoxy-1-methyl-2-(1-(2,2,2-trifluoroethyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)-1H-benzo[d]imidazol-5-yl)methanone

Produkt 1

HCID 131733421(R)-(3-Aminopiperidin-1-yl)(7-methoxy-1-methyl-2-(1-(2,2,2-trifluoroethyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)-1H-benzo[d]imidazol-5-yl)methanone, hydrochlorideAusbeute 102,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

(R)-(3-Aminopiperidin-1-yl)(7-methoxy-1-methyl-2-(1-(2,2,2-trifluoroethyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)-1H-benzo[d]imidazol-5-yl)methanone (1.5073 g) was dissolved in DCM (5 ml) and HCl (2M in diethyl ether) (1.5 ml, 3.00 mmol) was added to the solution. The solvent was then removed under nitrogen and concentrated under vacuum to afford the title compound as a white solid (1.61 g)

Aufarbeitung

  1. customThe solvent was then removed under nitrogen
  2. concentrationconcentrated under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-b7ce77abccff4a6b8331b11354f0e5dc
Quelldatensatz
uspto-grants-2015_09
Patentnummer
US09127003B2

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