Sodium hydride → HCID 14352181, Verbindung

HRID 2275216Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2275216
[H-].[Na+].[OH:3][CH2:4][C@H:5]1[O:9][C:8]([CH3:11])([CH3:10])[O:7][C@@H:6]1[CH2:12][OH:13].[CH3:14][C:15]([Si:18](Cl)([CH3:20])[CH3:19])([CH3:17])[CH3:16].C(=O)([O-])O.[Na+]>C1COCC1>[Si:18]([O:13][CH2:12][CH:6]1[O:7][C:8]([CH3:10])([CH3:11])[O:9][CH:5]1[CH2:4][OH:3])([C:15]([CH3:17])([CH3:16])[CH3:14])([CH3:20])[CH3:19]

Komponenten

6

Edukt 4

HCID 24758Sodium hydrideHCID 28928tert-Butyldimethylsilyl chlorideHCID 516892Sodium BicarbonateHCID 785244(-)-2,3-O-Isopropylidene-D-threitol

Produkt 1

HCID 14352181HCID 14352181, VerbindungAusbeute 95.801,797 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To THF (50 mL), NaH (1.41 g, 0.032 mmol) was added at room temperature, followed by addition of ((4R,5R)-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-methanol (5.0 g, 0.031 mmol) at room temperature. The mixture was stirred at room temperature for 1 hr. After that, TBSCl (5.11 g, 0.034 mmol) was added at room temperature and stirred at room temperature overnight. The reaction solution was added with saturated aqueous solution of sodium hydrogen carbonate and extracted with ethyl acetate. The organic layer was dried over magnesium sulfate. The residues obtained after concentration under reduced pressure were purified by silica gel column chromatography (ethyl acetate/hexane) to obtain the title compound (8.21 g, 96%).

Aufarbeitung

  1. stirringstirred at room temperature overnight
  2. extractionextracted with ethyl acetate
  3. dry with materialThe organic layer was dried over magnesium sulfate
  4. customThe residues obtained
  5. concentrationafter concentration under reduced pressure
  6. customwere purified by silica gel column chromatography (ethyl acetate/hexane)

Quellen und Nachweise

ORD-Eintrag
ord-96e730530b2c452caa63cca8283d8a66
Quelldatensatz
uspto-grants-2015_09
Patentnummer
US09126931B2

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