1-Pyrrolidinecarboxylic acid, 2-oxo-, 1,1-dimethylethyl ester → tert-butyl N-[4-(3-fluorophenyl)-4-oxobutyl]carbamate

Temperatur

-78 °C

In a round-bottomed flask was charged tert-butyl 2-oxopyrrolidine-1-carboxylate (2.2 g, 11.9 mmol) and THF (25 mL). The mixture was cooled down to −78° C. first, followed by slow addition of (3-fluorophenyl)magnesium bromide (17.8 mL, 17.8 mmol, 1.0 M solution in THF) over 15 minutes. The mixture was stirred for 3 hours, during which time the bath temperature rose from −78° C. to −10° C. The reaction was quenched by drop-wise addition of 1N HCl (2 mL) and warmed up to ambient temperature, followed by addition of EtOAc and water. After separating the organic layer, the aqueous layer was extracted with EtOAc three times. The combined organic layers was dried over Na2SO4 and concentrated to yield the product as a clear oil.

1. customrose from −78° C. to −10° C
2. customThe reaction was quenched by drop-wise addition of 1N HCl (2 mL)
3. temperaturewarmed up to ambient temperature
4. additionfollowed by addition of EtOAc and water
5. customAfter separating the organic layer
6. extractionthe aqueous layer was extracted with EtOAc three times
7. dry with materialThe combined organic layers was dried over Na2SO4
8. concentrationconcentrated

ORD-Eintrag

ord-77a50d4f3c10483a9e22609fae4a53ca

Quelldatensatz

uspto-grants-2015_09

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US09127013B2